PDGF-D gene polymorphism is associated with increased cardiovascular mortality in elderly men.

ABSTRACT:

Background

Platelet-derived growth factor (PDGF) D has been reported to be active in fibroblasts, and in areas of myocardial infarction. In this longitudinal study we evaluated the association between PDGF-D polymorphism and cardiovascular mortality, and attempted to discover whether specific genotype differences regarding risk could be observed, and if gender differences could be seen.

Methods

Four hundred seventy-six elderly community participants were included in this study. All participants underwent a clinical examination, echocardiography, and blood sampling including PDGF-D single nucleotide polymorphism (SNP) analyses of the rs974819 A/A, G/A and G/G SNP. The follow-up time was 6.7 years.

Results

No specific genotype of rs974819 demonstrated increased cardiova

SUBMITTER: Alehagen U 

PROVIDER: S-EPMC5009508 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature