Finishing monkeypox genomes from short reads: assembly analysis and a neural network method.

ABSTRACT:

Background

Poxviruses constitute one of the largest and most complex animal virus families known. The notorious smallpox disease has been eradicated and the virus contained, but its simian sister, monkeypox is an emerging, untreatable infectious disease, killing 1 to 10 % of its human victims. In the case of poxviruses, the emergence of monkeypox outbreaks in humans and the need to monitor potential malicious release of smallpox virus requires development of methods for rapid virus identification. Whole-genome sequencing (WGS) is an emergent technology with increasing application to the diagnosis of diseases and the identification of outbreak pathogens. But "finishing" such a genome is a laborious and time-consuming process, not easily automated. To date the large, complete poxviru

SUBMITTER: Zhao K 

PROVIDER: S-EPMC5009526 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature