Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin.

ABSTRACT:

Background

Beta-catenin has two major functions: coordinating cell-cell adhesion by interacting with cadherin in cadherin junction formation pathway; and regulating gene expression through Wnt signaling pathway. Accomplishing these two functions requires synergistic action of various sequential regions of the same beta-Catenin molecule, including the N-terminal tail, the middle armadillo domain, and the C-terminal tail. Although the middle armadillo domain is the major functional unit of beta-Catenin, the involvement of tails in the regulation of interaction between beta-Catenin and its partners has been well observed. Nonetheless, the regulatory processes of both tails are still elusive. In addition, it is interesting to note that the three sequential regions have different struct

SUBMITTER: Zhao B 

PROVIDER: S-EPMC5009561 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature