MiR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
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ABSTRACT:
SUBMITTER: Salta E
PROVIDER: S-EPMC5009807 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
Salta Evgenia E Sierksma Annerieke A Vanden Eynden Elke E De Strooper Bart B
EMBO molecular medicine 20160901 9
microRNA-132 (miR-132) is involved in prosurvival, anti-inflammatory and memory-promoting functions in the nervous system and has been found consistently downregulated in Alzheimer's disease (AD). Whether and how miR-132 deficiency impacts AD pathology remains, however, unaddressed. We show here that miR-132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5-trisphosphate 3-kinase B (ITPKB) upregulation in an AD mouse model. This leads to increased ERK1/2 and BACE1 activity and e ...[more]
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