Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors.

ABSTRACT: Natural killer (NK) cells are critical players against tumors. The outcome of anti-tumor vaccination protocols depends on the efficiency of NK-cell activation, and efforts are constantly made to manipulate them for immunotherapeutic approaches. Thus, a better understanding of NK-cell activation dynamics is needed. NK-cell interactions with accessory cells and trafficking between secondary lymphoid organs and tumoral tissues remain poorly characterized. Here, we show that upon triggering innate immunity with lipopolysaccharide (LPS), NK cells are transiently activated, leave the lymph node, and infiltrate the tumor, delaying its growth. Interestingly, NK cells are not actively recruited at the draining lymph node early after LPS administration, but continue their regular homeostatic turnove

SUBMITTER: Mingozzi F 

PROVIDER: S-EPMC5009809 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature