Chromosomal Rearrangements as Barriers to Genetic Homogenization between Archaic and Modern Humans.

ABSTRACT: Chromosomal rearrangements, which shuffle DNA throughout the genome, are an important source of divergence across taxa. Using a paired-end read approach with Illumina sequence data for archaic humans, I identify changes in genome structure that occurred recently in human evolution. Hundreds of rearrangements indicate genomic trafficking between the sex chromosomes and autosomes, raising the possibility of sex-specific changes. Additionally, genes adjacent to genome structure changes in Neanderthals are associated with testis-specific expression, consistent with evolutionary theory that new genes commonly form with expression in the testes. I identify one case of new-gene creation through transposition from the Y chromosome to chromosome 10 that combines the 5'-end of the testis-specific ge

SUBMITTER: Rogers RL 

PROVIDER: S-EPMC5009956 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature