Evaluating Phylostratigraphic Evidence for Widespread De Novo Gene Birth in Genome Evolution.

ABSTRACT: The source of genetic novelty is an area of wide interest and intense investigation. Although gene duplication is conventionally thought to dominate the production of new genes, this view was recently challenged by a proposal of widespread de novo gene origination in eukaryotic evolution. Specifically, distributions of various gene properties such as coding sequence length, expression level, codon usage, and probability of being subject to purifying selection among groups of genes with different estimated ages were reported to support a model in which new protein-coding proto-genes arise from noncoding DNA and gradually integrate into cellular networks. Here we show that the genomic patterns asserted to support widespread de novo gene origination are largely attributable to biases in gene

SUBMITTER: Moyers BA 

PROVIDER: S-EPMC5010002 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature