Increase HDL-C level over the menopausal transition is associated with greater atherosclerotic progression.

ABSTRACT:

Background

Experimental and observational evidence demonstrates that high-density lipoprotein (HDL) can lose its well-documented atheroprotective functions and even adopt a paradoxically proinflammatory nature in certain conditions. Hormonal alterations, especially estradiol reduction, influence the accumulation of risk factors that could potentially impair the quality of HDL during the menopausal transition (MT). Limited data exist to evaluate the relationship between changes in HDL-cholesterol (HDL-C) and its main carried protein, apolipoprotein A (apoA), over the MT, and atherosclerosis development.

Objective

To evaluate the associations of changes in HDL-C and apoA with progression of carotid intima-media thickness (cIMT), carotid adventitial diameter (cAD), and presence

SUBMITTER: El Khoudary SR 

PROVIDER: S-EPMC5010007 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature