Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.

ABSTRACT: Transposable elements (TEs) comprise large fractions of many eukaryotic genomes and imperil host genome integrity. The host genome combats these challenges by encoding proteins that silence TE activity. Both the introduction of new TEs via horizontal transfer and TE sequence evolution requires constant innovation of host-encoded TE silencing machinery to keep pace with TEs. One form of host innovation is the adaptation of existing, single-copy host genes. Indeed, host suppressors of TE replication often harbor signatures of positive selection. Such signatures are especially evident in genes encoding the piwi-interacting-RNA pathway of gene silencing, for example, the female germline-restricted TE silencer, HP1D/Rhino Host genomes can also innovate via gene duplication and divergence. Howev

SUBMITTER: Levine MT 

PROVIDER: S-EPMC5010033 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature