Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation.

ABSTRACT: DNA methylation is an epigenetic mechanism critical for tissue development and cell specification. Mammalian brains consist of many different types of cells with assumedly distinct DNA methylation profiles, and thus some genomic loci may demonstrate bipolar DNA methylation pattern, i.e. hypermethylated in one cell subset but hypomethylated in others. Currently, how extensive methylation patterns vary among brain cells is unknown and bipolar methylated genomic loci remain largely unexplored. In this study, we implemented a procedure to infer cell-subset specific methylated (CSM) loci from the methylomes of human and mouse frontal cortices at different developmental stages. With the genome-scale hairpin bisulfite sequencing approach, we demonstrated that the majority of CSM loci predicted li

SUBMITTER: Sun MA 

PROVIDER: S-EPMC5010034 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature