Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion.

ABSTRACT:

Aims

Recent studies have identified unique brain effects of insulin detemir (Levemir®). Due to its pharmacologic properties, insulin detemir may reach higher concentrations in the brain than regular insulin. This might explain the observed increased brain stimulation after acute insulin detemir application but it remained unclear whether chronic insulin detemir treatment causes alterations in brain activity as a consequence of overstimulation.

Methods

In mice, we examined insulin detemir's prolonged brain exposure by continuous subcutaneous (s.c.) application using either micro-osmotic pumps or daily s.c. injections and performed continuous radiotelemetric electrocorticography and locomotion recordings.

Results

Acute intracerebroventricular injection of insulin detemi

SUBMITTER: Sartorius T 

PROVIDER: S-EPMC5010192 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature