Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis.

ABSTRACT: Aging-associated alterations of cellular functions have been implicated in various disorders including cancers. Due to difficulties in identifying aging cells in living tissues, most studies have focused on aging-associated changes in whole tissues or certain cell pools. Thus, it remains unclear what kinds of alterations accumulate in each cell during aging. While analyzing several mouse lines expressing fluorescent proteins (FPs), we found that expression of FPs is gradually silenced in the intestinal epithelium during aging in units of single crypt composed of clonal stem cell progeny. The cells with low FP expression retained the wild-type Apc allele and the tissues composed of them did not exhibit any histological abnormality. Notably, the silencing of FPs was also observed in intestin

SUBMITTER: Okuchi Y 

PROVIDER: S-EPMC5010213 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature