Genomic and Metabolomic Profile Associated to Clustering of Cardio-Metabolic Risk Factors.

ABSTRACT:

Background

To identify metabolomic and genomic markers associated with the presence of clustering of cardiometabolic risk factors (CMRFs) from a general population.

Methods and findings

One thousand five hundred and two subjects, Caucasian, > 18 years, representative of the general population, were included. Blood pressure measurement, anthropometric parameters and metabolic markers were measured. Subjects were grouped according the number of CMRFs (Group 1: <2; Group 2: 2; Group 3: 3 or more CMRFs). Using SNPlex, 1251 SNPs potentially associated to clustering of three or more CMRFs were analyzed. Serum metabolomic profile was assessed by 1H NMR spectra using a Brucker Advance DRX 600 spectrometer. From the total population, 1217 (mean age 54±19, 50.6% men) with high genotyp

SUBMITTER: Marrachelli VG 

PROVIDER: S-EPMC5010244 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature