Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis.

ABSTRACT:

Rationale

Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as an important component of inflammatory processes in atherosclerosis. Mitochondrial DNA (mtDNA) damage is detrimental in atherosclerosis, and mitochondria are central regulators of the nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 inflammasome. Human atherosclerotic plaques express increased mtDNA damage. The major DNA glycosylase, 8-oxoguanine glycosylase (OGG1), is responsible for removing the most abundant form of oxidative DNA damage.

Objective

To test the role of OGG1 in the development of atherosclerosis in mouse.

Methods and results

We observed that Ogg1 expre

SUBMITTER: Tumurkhuu G 

PROVIDER: S-EPMC5010464 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature