APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.

ABSTRACT:

Objective

Apolipoprotein E (apoE), a major cholesterol carrier in the brain, is associated with a strong risk for Alzheimer disease. Compared to the risky APOE4 gene allele, the effects of the protective APOE2 gene allele are vastly understudied, and thus need to be further clarified.

Methods

We reviewed National Alzheimer's Coordinating Center clinical records and performed preclinical experiments using human apoE-targeted replacement (apoE-TR) mice, which do not show amyloid pathology.

Results

Clinically, the APOE2 allele was associated with less cognitive decline during aging. This effect was also seen in subjects with little amyloid pathology, or after adjusting for Alzheimer disease-related pathologies. In animal studies, aged apoE2-TR mice also exhibited preserv

SUBMITTER: Shinohara M 

PROVIDER: S-EPMC5010530 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature