Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp.

ABSTRACT:

Background

The nurse cell (NC) constitutes in mammalian skeletal muscles a confined intracellular niche to support the metabolic needs of muscle larvae of Trichinella spp. encapsulating species. The main biological functions of NC were identified as hypermitogenic growth arrest and pro-inflammatory phenotype, both inferred to depend on AP-1 (activator protein 1) transcription factor. Since those functions, as well as AP-1 activity, are known to be regulated among other pathways, also by Wnt (Wingless-Type of Mouse Mammary Tumor Virus Integration Site) signaling, transcription profiling of molecules participating in Wnt signaling cascades in NC, was performed.

Methods

Wnt signaling-involved gene expression level was measured by quantitative RT-PCR approach with the use of Qia

SUBMITTER: Dabrowska M 

PROVIDER: S-EPMC5010673 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature