Low genetic diversity among historical and contemporary clinical isolates of felid herpesvirus 1.

ABSTRACT:

Background

Felid herpesvirus 1 (FHV-1) causes upper respiratory tract diseases in cats worldwide, including nasal and ocular discharge, conjunctivitis and oral ulceration. The nature and severity of disease can vary between clinical cases. Genetic determinants of virulence are likely to contribute to differences in the in vivo phenotype of FHV-1 isolates, but to date there have been limited studies investigating FHV-1 genetic diversity. This study used next generation sequencing to compare the genomes of contemporary Australian clinical isolates of FHV-1, vaccine isolates and historical clinical isolates, including isolates that predated the introduction of live attenuated vaccines into Australia. Analysis of the genome sequences aimed to assess the level of genetic diversity, iden

SUBMITTER: Vaz PK 

PROVIDER: S-EPMC5010698 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature