Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius.

ABSTRACT: Hibernation is a complex physiological response that some mammalian species employ to evade energetic demands. Previous work in mammalian hibernators suggests that hibernation is activated not by a set of genes unique to hibernators, but by differential expression of genes that are present in all mammals. This question of universal genetic mechanisms requires further investigation and can only be tested through additional investigations of phylogenetically dispersed species. To explore this question, we use RNA-Seq to investigate gene expression dynamics as they relate to the varying physiological states experienced throughout the year in a group of primate hibernators-Madagascar's dwarf lemurs (genus Cheirogaleus). In a novel experimental approach, we use longitudinal sampling of biologic

SUBMITTER: Faherty SL 

PROVIDER: S-EPMC5010898 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature