Expansion of brain T cells in homeostatic conditions in lymphopenic Rag2(-/-) mice.

ABSTRACT: The concept of the brain as an immune privileged organ is rapidly evolving in light of new findings outlining the sophisticated relationship between the central nervous and the immune systems. The role of T cells in brain development and function, as well as modulation of behavior has been demonstrated by an increasing number of studies. Moreover, recent studies have redefined the existence of a brain lymphatic system and the presence of T cells in specific brain structures, such as the meninges and choroid plexus. Nevertheless, much information is needed to further the understanding of brain T cells and their relationship with the central nervous system under non-inflammatory conditions. In the present study we employed the Rag2(-/-) mouse model of lymphocyte deficiency and reconstitution

SUBMITTER: Song C 

PROVIDER: S-EPMC5010944 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature