Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis.

ABSTRACT:

Objective

To determine expression of stanniocalcin-1 (STC1) in human endometrium with and without endometriosis and its regulation by steroid hormones.

Design

Laboratory study.

Setting

University.

Patient(s)

Nineteen women with endometriosis and 33 control women.

Intervention(s)

Endometrial biopsy and fluid sampling.

Main outcome measure(s)

Analysis of early secretory (ESE) and midsecretory (MSE) endometrial secretomes from fertile women with the use of nano-liquid chromatography-dual mass spectrometry; real-time quantitative polymerase chain reaction, and immunohistochemistry for STC1 and its receptor calcium-sensing receptor (CASR) mRNA and proteins in endometrium with and without endometriosis; evaluation of STC1 and CASR mRNA expression in end

SUBMITTER: Aghajanova L 

PROVIDER: S-EPMC5010972 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature