Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback.

ABSTRACT: Inflammation, part of the body's innate immune response, can lead to "sickness behaviors," as well as alterations in social and affective experiences. Elevated levels of pro-inflammatory cytokines have been associated with increased neural sensitivity to social rejection and social threat, but also decreased neural sensitivity to rewards. However, recent evidence suggests that inflammation may actually enhance sensitivity to certain social rewards, such as those that signal support and care. Despite a growing interest in how inflammation influences neural reactivity to positive and negative social experiences, no known studies have investigated these processes in the same participants, using a similar task. To examine this issue, 107 participants were randomly assigned to receive either pl

SUBMITTER: Muscatell KA 

PROVIDER: S-EPMC5011017 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature