Prenatal and postnatal stress and asthma in children: Temporal- and sex-specific associations.

ABSTRACT:

Background

Temporal- and sex-specific effects of perinatal stress have not been examined for childhood asthma.

Objectives

We examined associations between prenatal and/or postnatal stress and children's asthma (n = 765) and effect modification by sex in a prospective cohort study.

Methods

Maternal negative life events were ascertained prenatally and postpartum. Negative life event scores were categorized as 0, 1 to 2, 3 to 4, or 5 or greater to assess exposure-response relationships. We examined effects of prenatal and postnatal stress on children's asthma by age 6 years, modeling each as independent predictors, mutually adjusting for prenatal and postnatal stress, and finally considering interactions between prenatal and postnatal stress. Effect modification by sex w

SUBMITTER: Lee A 

PROVIDER: S-EPMC5011027 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature