Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections.

ABSTRACT: Acute aortic dissections are a preventable cause of sudden death if individuals at risk are identified and surgically repaired in a non-emergency setting. Although mutations in single genes can be used to identify at-risk individuals, the majority of dissection case subjects do not have evidence of a single gene disorder, but rather have the other major risk factor for dissections, hypertension. Initial genome-wide association studies (GWASs) identified SNPs at the FBN1 locus associated with both thoracic aortic aneurysms and dissections. Here, we used the Illumina HumanExome array to genotype 753 individuals of European descent presenting specifically with non-familial, sporadic thoracic aortic dissection (STAD) and compared them to the genotypes of 2,259 control subjects from the Atheros

SUBMITTER: Guo DC 

PROVIDER: S-EPMC5011062 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature