Vitamin D receptor gene associations with pulmonary tuberculosis in a Tibetan Chinese population.

ABSTRACT:

Background

The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis.

Methods

This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an. Association analyses of SNPs in VDR were performed with the SPSS 17.0 statistical packages, SNP stats software, Haploview software package (version 4.2), and the SHEsis software platform.

Results

Our results revealed a correlation between three SNPs (rs11574143, odds ratio [OR]: 1.47, 95 % confidence interval [CI]

SUBMITTER: Hu Q 

PROVIDER: S-EPMC5011340 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature