Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.

ABSTRACT:

Background

Adult skeletal muscles are composed of slow and fast myofiber subtypes which each express selective genes required for their specific contractile and metabolic activity. Six homeoproteins are transcription factors regulating muscle cell fate through activation of myogenic regulatory factors and driving fast-type gene expression during embryogenesis.

Results

We show here that Six1 protein accumulates more robustly in the nuclei of adult fast-type muscles than in adult slow-type muscles, this specific enrichment takes place during perinatal growth. Deletion of Six1 in soleus impaired fast-type myofiber specialization during perinatal development, resulting in a slow phenotype and a complete lack of Myosin heavy chain 2A (MyHCIIA) expression. Global transcriptomic an

SUBMITTER: Sakakibara I 

PROVIDER: S-EPMC5011358 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature