The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI.

ABSTRACT: High field magnetic resonance imaging (MRI)-based delineation of the substantia nigra (SN) and visualization of its inner cellular organization are promising methods for the evaluation of morphological changes associated with neurodegenerative diseases; however, corresponding MR contrasts must be matched and validated with quantitative histological information. Slices from two postmortem SN samples were imaged with a 7 Tesla (7T) MRI with T1 and T2* imaging protocols and then stained with Perl's Prussian blue, Kluver-Barrera, tyrosine hydroxylase, and calbindin immunohistochemistry in a serial manner. The association between T2* values and quantitative histology was investigated with a co-registration method that accounts for histology slice preparation. The ventral T2* hypointense layers

SUBMITTER: Lee JH 

PROVIDER: S-EPMC5011647 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature