Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions.

ABSTRACT: Cancer stem cells (CSCs), or cancer cells with stem cell-like properties, generally exhibit drug resistance and have highly potent cancer inducing capabilities. Genome-wide expression data collected at public repositories over the last few years provide excellent material for studies that can lead to insights concerning the molecular and functional characteristics of CSCs. Here, we conducted functional genomic studies of CSC based on fourteen PCA-screened high quality public CSC whole genome gene expression datasets and, as control, four high quality non-stem-like cancer cell and non-cancerous stem cell datasets from the Gene Expression Omnibus database. A total of 6,002 molecular signatures were taken from the Molecular Signatures Database and used to characterize the datasets, which, und

SUBMITTER: Hsu CL 

PROVIDER: S-EPMC5011650 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature