The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults.

ABSTRACT: Neonates are more susceptible to infections than adults. This susceptibility is thought to reflect neonates' qualitative and quantitative defects in the adaptive and innate immune responses. Differential expression of cell surface receptors may result in altered thresholds of neonatal immune cell activation. We determined whether the expression and function of the lipid-binding CD300 family of receptors are different on neonatal immune cells compared to adult immune cells. A multiparametric flow cytometry analysis was performed to determine the expression of CD300 receptors on adult peripheral blood mononuclear cells and neonatal cord blood mononuclear cells. The expression of the CD300a inhibitory receptor was significantly reduced on cells from the newborn adaptive immune system, and neo

SUBMITTER: Zenarruzabeitia O 

PROVIDER: S-EPMC5011699 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature