Phenotypic and Genetic Correlations Between the Lobar Segments of the Inferior Fronto-occipital Fasciculus and Attention.

ABSTRACT: Attention deficits may present dysfunctions in any one or two components of attention (alerting, orienting, and executive control (EC)). However, these various forms of attention deficits generally have abnormal microstructure integrity of inferior fronto-occipital fasciculus (IFOF). In this work, we aim to deeply explore: (1) associations between microstructure integrities of IFOF (including frontal, parietal, temporal, occipital, and insular segments) and attention by means of structural equation models and multiple regression analyses; (2) genetic/environmental effects on IFOF, attention, and their correlations using bivariate genetic analysis. EC function was attributed to the fractional anisotropy (FA) of left (correlation was driven by genetic and environmental factors) and right IFO

SUBMITTER: Leng Y 

PROVIDER: S-EPMC5011720 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature