Biomarkers of inflammation and innate immunity in atrophic nonunion fracture.

ABSTRACT:

Background

Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

Methods

Thirty-three atrophic nonunion (NU) patients that failed to demonstrate any radiographic improvement for 6 consecutive months were recruited for providing serum samples. Thirty-five healthy volunteers (HV) served as the control group. Proteomics studies were performed using SELDI-TOF-MS and 2D-DIGE approaches, associated or not with Proteominer® preprocessing, to highlight biomarkers specific to atrophic nonunion pathology. Peak intensities were analyzed by two statistical approaches, a nonparametric Mann-Whitney U tests (univariate approach) and a machine-learning algo

SUBMITTER: de Seny D 

PROVIDER: S-EPMC5011805 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature