Evaluating the accuracy of protein design using native secondary sub-structures.

ABSTRACT:

Background

According to structure-dependent function of proteins, two main challenging problems called Protein Structure Prediction (PSP) and Inverse Protein Folding (IPF) are investigated. In spite of IPF essential applications, it has not been investigated as much as PSP problem. In fact, the ultimate goal of IPF problem or protein design is to create proteins with enhanced properties or even novel functions. One of the major computational challenges in protein design is its large sequence space, namely searching through all plausible sequences is impossible. Inasmuch as, protein secondary structure represents an appropriate primary scaffold of the protein conformation, undoubtedly studying the Protein Secondary Structure Inverse Folding (PSSIF) problem is a quantum leap forward

SUBMITTER: Movahedi M 

PROVIDER: S-EPMC5011913 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature