Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasia.

ABSTRACT:

Background and study aims

To demonstrate the clinical use of a multimodal endoscope with a targeted fluorescently labeled peptide for quantitative detection of Barrett's neoplasia.

Patients and methods

We studied 50 patients with Barrett's esophagus using a prototype multimodal endoscope with a fluorescently labeled peptide. Co-registered fluorescence and reflectance images were converted to ratios to correct for differences in distance and geometry over the image field of view. The ratio images were segmented using a unique threshold that maximized the variance between high and low intensities to localize regions of high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC).

Results

Early neoplasia (HGD and EAC) was identified with 94 % specificity and 96 % posit

SUBMITTER: Joshi BP 

PROVIDER: S-EPMC5011967 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature