Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives.

ABSTRACT: The increasing demand for liver transplantation and the decline in donor organs has highlighted the need for alternative novel therapies to prevent chronic active hepatitis, which eventually leads to liver cirrhosis and liver cancer. Liver histology of chronic hepatitis is composed of both effector and regulatory lymphocytes. The human liver contains different subsets of effector lymphocytes that are kept in check by a subpopulation of T cells known as Regulatory T cells (Treg). The balance of effector and regulatory lymphocytes generally determines the outcome of hepatic inflammation: resolution, fulminant hepatitis, or chronic active hepatitis. Thus, maintaining and adjusting this balance is crucial in immunological manipulation of liver diseases. One of the options to restore this balan

SUBMITTER: Jeffery HC 

PROVIDER: S-EPMC5012133 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature