Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation.

ABSTRACT: Brain inflammation, a common feature in neurodegenerative diseases, is a complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencing neural cell proliferation, survival, migration, and differentiation. Recently, correlative studies suggested that astrocytes are able to dedifferentiate upon injury and may thereby re-acquire neural stem cell (NSC) potential. However, the mechanism underlying this dedifferentiation process upon injury remains unclear. Here, we report that during the early response of reactive gliosis, inflammation induces a conversion of mature astrocytes into neural progenitors. A TNF treatment induces the decrease of specific astrocyte markers, such as glia

SUBMITTER: Gabel S 

PROVIDER: S-EPMC5012156 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature