Analysis of genotype diversity and evolution of Dengue virus serotype 2 using complete genomes.

ABSTRACT:

Background

Dengue is one of the most common arboviral diseases prevalent worldwide and is caused by Dengue viruses (genus Flavivirus, family Flaviviridae). There are four serotypes of Dengue Virus (DENV-1 to DENV-4), each of which is further subdivided into distinct genotypes. DENV-2 is frequently associated with severe dengue infections and epidemics. DENV-2 consists of six genotypes such as Asian/American, Asian I, Asian II, Cosmopolitan, American and sylvatic. Comparative genomic study was carried out to infer population structure of DENV-2 and to analyze the role of evolutionary and spatiotemporal factors in emergence of diversifying lineages.

Methods

Complete genome sequences of 990 strains of DENV-2 were analyzed using Bayesian-based population genetics and phylogeneti

SUBMITTER: Waman VP 

PROVIDER: S-EPMC5012332 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature