The Interplay of Temperature and Genotype on Patterns of Alternative Splicing in Drosophila melanogaster.

ABSTRACT: Alternative splicing is the highly regulated process of variation in the removal of introns from premessenger-RNA transcripts. The consequences of alternative splicing on the phenotype are well documented, but the impact of the environment on alternative splicing is not yet clear. We studied variation in alternative splicing among four different temperatures, 13, 18, 23, and 29°, in two Drosophila melanogaster genotypes. We show plasticity of alternative splicing with up to 10% of the expressed genes being differentially spliced between the most extreme temperatures for a given genotype. Comparing the two genotypes at different temperatures, we found <1% of the genes being differentially spliced at 18°. At extreme temperatures, however, we detected substantial differences in alternative sp

SUBMITTER: Jaksic AM 

PROVIDER: S-EPMC5012396 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature