DNA methylation of lipid-related genes affects blood lipid levels.

ABSTRACT:

Background

Epigenetic mechanisms might be involved in the regulation of interindividual lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this study was to investigate the association between genome-wide DNA methylation and blood lipid levels high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and total cholesterol. Observed DNA methylation changes were also further analyzed to examine their relationship with previous hospitalized myocardial infarction.

Methods and results

Genome-wide DNA methylation patterns were determined in whole blood samples of 1776 subjects of the Cooperative Health Research in the Region of Augsburg F4 cohort using the Infinium HumanMethylation450 BeadChip (Illumina).

SUBMITTER: Pfeiffer L 

PROVIDER: S-EPMC5012424 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature