Inflammation and Progression of CKD: The CRIC Study.

ABSTRACT:

Background and objectives

CKD is a global public health problem with significant mortality and morbidity.

Design, setting, participants, & measurements

We examined the multivariable association of plasma levels of IL-1, IL-1 receptor antagonist, IL-6, TNF-α, TGF-β, high-sensitivity C-reactive protein, fibrinogen, and serum albumin with progression of CKD in 3430 Chronic Renal Insufficiency Cohort study participants.

Results

Over a median follow-up time of 6.3 years, 899 participants reached the composite end point of ≥50% decline in eGFR from baseline or onset of ESRD. Elevated plasma levels of fibrinogen, IL-6, and TNF-α and lower serum albumin were associated with a greater decline in eGFR over time. After adjusting for demographics, BP, laboratory variables, medica

SUBMITTER: Amdur RL 

PROVIDER: S-EPMC5012490 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature