Ontology highlight
ABSTRACT:
SUBMITTER: Loiseau C
PROVIDER: S-EPMC5012605 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Loiseau Clémence C Augenstreich Jacques J Marchand Adrienne A Harté Etienne E Garcia Martine M Verdon Julien J Mesnil Marc M Lecomte Sophie S Berjeaud Jean-Marc JM
PloS one 20160906 9
Antimicrobial peptides can be used as therapeutic agents against cancer cells. Warnericin RK and derivatives (WarnG20D and WarnF14V) were tested on various, solid tumor or leukemia, cancer cells. These peptides appeared to be cytotoxic on all the cell types tested, cancerous as well healthy, but very interestingly displayed no deleterious effect on healthy mononuclear cells. The mode of action of the peptide was proposed to be membranolytic, using chemical Raman imaging. Addition of peptide indu ...[more]