Development of a risk stratification system to guide treatment for female germ cell tumors.

ABSTRACT:

Objective

Due to their rarity, little is known about prognostic factors in female germ cell tumors (GCTs) or outcomes following systemic therapy. Management is largely based on studies of male GCT and epithelial ovarian cancer.

Methods

Chart review was performed for all females with GCT seen at Memorial Sloan Kettering Cancer Center (MSKCC) from 1990 to 2012. Patients receiving chemotherapy were stratified using a modification of the male IGCCCG risk system, and the classifier was correlated with outcome.

Results

Of 93 patients, 92 (99%) underwent primary surgery and 85 (92%) received chemotherapy. Modified IGCCCG classification was significantly associated with progression-free survival (PFS) and overall survival (OS), both when applied preoperatively and pre-chemoth

SUBMITTER: Meisel JL 

PROVIDER: S-EPMC5012648 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature