Global Profiling of the Cellular Alternative RNA Splicing Landscape during Virus-Host Interactions.

ABSTRACT: Alternative splicing (AS) is a central mechanism of genetic regulation which modifies the sequence of RNA transcripts in higher eukaryotes. AS has been shown to increase both the variability and diversity of the cellular proteome by changing the composition of resulting proteins through differential choice of exons to be included in mature mRNAs. In the present study, alterations to the global RNA splicing landscape of cellular genes upon viral infection were investigated using mammalian reovirus as a model. Our study provides the first comprehensive portrait of global changes in the RNA splicing signatures that occur in eukaryotic cells following infection with a human virus. We identify 240 modified alternative splicing events upon infection which belong to transcripts frequently involve

SUBMITTER: Boudreault S 

PROVIDER: S-EPMC5012649 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature