Transition between Functional Regimes in an Integrate-And-Fire Network Model of the Thalamus.

ABSTRACT: The thalamus is a key brain element in the processing of sensory information. During the sleep and awake states, this brain area is characterized by the presence of two distinct dynamical regimes: in the sleep state activity is dominated by spindle oscillations (7 - 15 Hz) weakly affected by external stimuli, while in the awake state the activity is primarily driven by external stimuli. Here we develop a simple and computationally efficient model of the thalamus that exhibits two dynamical regimes with different information-processing capabilities, and study the transition between them. The network model includes glutamatergic thalamocortical (TC) relay neurons and GABAergic reticular (RE) neurons described by adaptive integrate-and-fire models in which spikes are induced by either depolar

SUBMITTER: Barardi A 

PROVIDER: S-EPMC5012668 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature