Exact Power and Sample Size Calculations for the Two One-Sided Tests of Equivalence.

ABSTRACT: Equivalent testing has been strongly recommended for demonstrating the comparability of treatment effects in a wide variety of research fields including medical studies. Although the essential properties of the favorable two one-sided tests of equivalence have been addressed in the literature, the associated power and sample size calculations were illustrated mainly for selecting the most appropriate approximate method. Moreover, conventional power analysis does not consider the allocation restrictions and cost issues of different sample size choices. To extend the practical usefulness of the two one-sided tests procedure, this article describes exact approaches to sample size determinations under various allocation and cost considerations. Because the presented features are not generally

SUBMITTER: Shieh G 

PROVIDER: S-EPMC5012670 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature