Safety of long-term use of linezolid: results of an open-label study.

ABSTRACT:

Objective

The objective of this study was to assess the long-term safety of linezolid in patients with chronic infections requiring treatment for ≥6 weeks. Enhanced monitoring for optic neuropathy was included to characterize the early development of this side effect and to identify ophthalmologic tests that might be valuable in early detection of this event.

Methods

This was a multicenter, open-label, pilot study of patients aged ≥18 years on long-term linezolid therapy. Matched control patients were included for baseline assessment comparison. Patients were assessed at study entry, monthly while on treatment, at the end of treatment, and 30 days following the last dose. Aggregate ocular safety data were reviewed. Response to treatment was reported.

Results

The study

SUBMITTER: Vazquez JA 

PROVIDER: S-EPMC5012852 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature