Gut microbiome predictors of treatment response and recurrence in primary Clostridium difficile infection.

ABSTRACT:

Background

Clostridium difficile infection (CDI) may not respond to initial therapy and frequently recurs, but predictors of response and recurrence are inconsistent. The impact of specific alterations in the gut microbiota determining treatment response and recurrence in patients with CDI is unknown.

Aim

To assess microbial signatures as predictors of treatment response and recurrence in CDI.

Methods

Pre-treatment stool samples and clinical metadata including outcomes were collected prospectively from patients with their first CDI episode. Next generation 16s rRNA sequencing using MiSeq Illumina platform was performed and changes in microbial community structure were correlated with CDI outcomes.

Results

Eighty-eight patients (median age 52.7 years, 60.2% fema

SUBMITTER: Khanna S 

PROVIDER: S-EPMC5012905 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature