Ontology highlight
ABSTRACT:
SUBMITTER: Strong R
PROVIDER: S-EPMC5013015 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Strong Randy R Miller Richard A RA Antebi Adam A Astle Clinton M CM Bogue Molly M Denzel Martin S MS Fernandez Elizabeth E Flurkey Kevin K Hamilton Karyn L KL Lamming Dudley W DW Javors Martin A MA de Magalhães João Pedro JP Martinez Paul Anthony PA McCord Joe M JM Miller Benjamin F BF Müller Michael M Nelson James F JF Ndukum Juliet J Rainger G Ed GE Richardson Arlan A Sabatini David M DM Salmon Adam B AB Simpkins James W JW Steegenga Wilma T WT Nadon Nancy L NL Harrison David E DE
Aging cell 20160616 5
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each compound is tested in parallel at three sites, and all results are published. We report the effects of lifelong treatment of mice with four agents not previously tested: Protandim, fish oil, ursodeoxycholic acid (UDCA) and metformin - the latter with and without rapamycin, and two drugs previously examined: 17-α-estradiol and nordi ...[more]