Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition.

ABSTRACT: Adverse environmental exposures of mothers during fetal period predispose offspring to a range of age-related diseases earlier in life. Here, we set to determine whether a deregulated epigenetic pattern is similar in young animals whose mothers' nutrition was modulated during fetal growth to that acquired during normal aging in animals. Using a rodent model of maternal undernutrition (UN) or overnutrition (ON), we examined cytosine methylation profiles of liver from young female offspring and compared them to age-matched young controls and aged (20-month-old) animals. HELP-tagging, a genomewide restriction enzyme and sequencing assay demonstrates that fetal exposure to two different maternal diets is associated with nonrandom dysregulation of methylation levels with profiles similar to tho

SUBMITTER: Heo HJ 

PROVIDER: S-EPMC5013021 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature