Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis.

ABSTRACT:

Background

Parkinson's disease (PD) is 1.5 times more frequent in men than women. Whether age modifies this ratio is unclear. We examined whether male-to-female (M-F) ratios change with age through a French nationwide prevalence/incidence study (2010) and a meta-analysis of incidence studies.

Methods

We used French national drug claims databases to identify PD cases using a validated algorithm. We computed M-F prevalence/incidence ratios overall and by age using Poisson regression. Ratios were regressed on age to estimate their annual change. We identified all PD incidence studies with age/sex-specific data, and performed a meta-analysis of M-F ratios.

Results

On the basis of 149 672 prevalent (50% women) and 25 438 incident (49% women) cases, age-standardised rates w

SUBMITTER: Moisan F 

PROVIDER: S-EPMC5013115 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature