Differences in globus pallidus neuronal firing rates and patterns relate to different disease biology in children with dystonia.

ABSTRACT:

Background

The pathophysiology underlying different types of dystonia is not yet understood. We report microelectrode data from the globus pallidus interna (GPi) and globus pallidus externa (GPe) in children undergoing deep brain stimulation (DBS) for dystonia and investigate whether GPi and GPe firing rates differ between dystonia types.

Methods

Single pass microelectrode data were obtained to guide electrode position in 44 children (3.3-18.1 years, median 10.7) with the following dystonia types: 14 primary, 22 secondary Static and 8 progressive secondary to neuronal brain iron accumulation (NBIA). Preoperative stereotactic MRI determined coordinates for the GPi target. Digitised spike trains were analysed offline, blind to clinical data. Electrode placement was confirmed b

SUBMITTER: McClelland VM 

PROVIDER: S-EPMC5013118 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature