Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b.

ABSTRACT:

Unlabelled

During embryonic development, regulation of gene expression is key to creating the many subtypes of cells that an organism needs throughout its lifetime. Recent work has shown that maternal genetics and environmental factors have lifelong consequences on diverse processes ranging from immune function to stress responses. The RE1-silencing transcription factor (Rest) is a transcriptional repressor that interacts with chromatin-modifying complexes to repress transcription of neural-specific genes during early development. Here we show that in zebrafish, maternally supplied rest regulates expression of target genes during larval development and has lifelong impacts on behavior. Larvae deprived of maternal rest are hyperactive and show atypical spatial preferences. Adult mal

SUBMITTER: Moravec CE 

PROVIDER: S-EPMC5013188 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature